Starting doses (typically 0.25 mg) produce modest appetite suppression, while therapeutic doses (1.0 to 2.4 mg) deliver the full weight loss benefit seen in clinical trials
Nevertheless, a recent comprehensive review has documented a variety of melatonin actions on the physiology of endocrine pancreas that would be expected to reduce the incidence of diabetes.11 Patients with coronary artery disease have low melatonin production rates and blood melatonin concentrations correlate with the severity of the disease, ie, greater reductions in melatonin production are observed in patients with a higher risk of myocardial infarction and/or sudden death
"Adems -contina-, se puede bajar de peso y perder masa muscular si no va acompaado de actividad fsica regular, y la prdida de masa muscular trae eventos cardiovasculares cuando no se hace de manera controlada", suma
Additionally, some patients experience headaches (a common side effect) and dizziness (less common), both of which can contribute to a general sense of unwellness and reduced energy
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